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Synthesis of novel indole substituted heterocyclics

By: Devendar, Ponnam.
Contributor(s): Niranjana, Kumar A.
Publisher: New Delhi CSIR 2022Edition: Vol.61, Jan.Description: 51-59p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here In: Indian journal of chemistry (Section B)Summary: Herein is reported the synthesis of a series (21 number) of novel hybrid molecules composed of an indole-3-carbaldehyde attached to triazole/ isoxazole/ isoxazoline moieties having various aromatic/benzylic/aliphatic substitutions via 1,3-dipolar cycloaddition between azide/ nitrile oxide (dipole) and indole substituted alkyne/ alkene (dipolarophile) based on the importance of indole, 1,2,3-triazole, isoxazole and isoxazoline containing pharmacophores.
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Herein is reported the synthesis of a series (21 number) of novel hybrid molecules composed of an indole-3-carbaldehyde attached to triazole/ isoxazole/ isoxazoline moieties having various aromatic/benzylic/aliphatic substitutions via 1,3-dipolar cycloaddition between azide/ nitrile oxide (dipole) and indole substituted alkyne/ alkene (dipolarophile) based on the importance of indole, 1,2,3-triazole, isoxazole and isoxazoline containing pharmacophores.

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